Hypoxia Induces Myocardial Regeneration in Zebrafish Running title: Jopling et al.; Hypoxia induces myocardial regeneration in zebrafish
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چکیده
3 Salk Institu ute te e f f for or r B B Bio io iolo lo logi gi gica ca c l l Me Me M ch c an anis is ism m ms o of f Re R ge gene nera r tion on, , La LabE Ex ICST T, , D Dép p partem emen ent de P P Phy hy h si siol olo ogie, Abstract: Background—Hypoxia plays an important role in many biological/pathological processes. In
منابع مشابه
Molecular Cardiology Hypoxia Induces Myocardial Regeneration in Zebrafish
Background—Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia. which, although initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely affecting cardiac functionality. Although myocardial damage/loss remains an insurmountable problem for adult mam...
متن کاملHypoxia induces myocardial regeneration in zebrafish.
BACKGROUND Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia. which, although initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely affecting cardiac functionality. Although myocardial damage/loss remains an insurmountable problem for adult mam...
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Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault prot...
متن کاملHypoxia/Reoxygenation Cardiac Injury and Regeneration in Zebrafish Adult Heart
AIMS the adult zebrafish heart regenerates spontaneously after injury and has been used to study the mechanisms of cardiac repair. However, no zebrafish model is available that mimics ischemic injury in mammalian heart. We developed and characterized zebrafish cardiac injury induced by hypoxia/reoxygenation (H/R) and the regeneration that followed it. METHODS AND RESULTS adult zebrafish were ...
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The human heart's failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to the worldwide morbidity and mortality associated with coronary artery disease. Remarkably, certain vertebrate species, including the zebrafish, achieve complete regeneration of amputated or injured myocardium through the proliferation of spared cardiomyocytes. Nonetheless, the g...
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